The Vaccines
MMR
INTERPRETATION: Our analyses do not support a causal association between MMR vaccine and autism. If such an association occurs, it is so rare that it could not be identified in this large regional sample.
MMRV
Measles-Mumps-Rubella-Varicella Combination Vaccine and the Risk of Febrile Seizures Nicola P. Klein, Bruce Fireman, W. Katherine Yih, Edwin Lewis, Martin Kulldorff, Paula Ray, Roger Baxter, Simon Hambidge, James Nordin, Allison Naleway, Edward A. Belongia, Tracy Lieu, James Baggs, and Eric Weintraub for the Vaccine Safety Datalink 2010;126;e1-e8; originally published online Jun 29, 2010; Pediatrics DOI: 10.1542/peds.2010-0665
CONCLUSION: Among 12- to 23-month-olds who received their first dose of measles-containing vaccine, fever and seizure were elevated 7 to 10 days after vaccination. Vaccination with MMRV results in 1 additional febrile seizure for every 2300 doses given instead of separate MMR + varicella vaccines. Providers who recommend MMRV should communicate to parents that it increases the risk of fever and seizure over that already associated with measles-containing vaccines.
Pneumococcal
CONCLUSION: The 23-valent pneumococcal polysaccharide vaccine prevented pneumococcal pneumonia and reduced mortality from pneumococcal pneumonia in nursing home residents.
Conclusion - A 2 + 1-dose PCV-7 schedule was associated with an increase in serotype 19A nasopharyngeal acquisition compared with unvaccinated controls.
Conclusion Childhood bacterial pneumonia and empyema admission rates were increasing prior to 2006 and decreased by 19% and 22% respectively between 2006 and 2008, following the introduction of the PCV7 pneumococcal conjugate vaccination to the national childhood immunisation programme.
Rotavirus
CONCLUSION: The introduction of the RV5 vaccine was associated with a dramatic reduction in hospitalizations for acute gastroenteritis among US children during the 2008 rotavirus season.
CONCLUSION: In infants in developing countries in Asia, pentavalent rotavirus vaccine is safe and efficacious against severe rotavirus gastroenteritis, and our results support expanded WHO recommendations to promote its global use.
CONCLUSION: Pentavalent rotavirus vaccine is effective against severe rotavirus gastroenteritis in the first 2 years of life in African countries with high mortality in infants younger than 5 years. We support WHO’s recommendation for adoption of rotavirus vaccine into national expanded programmes on immunisation in Africa.
CONCLUSION: Increased use of RV5 in a pediatric practice was associated with fewer AGE office visits and hospitalizations. The reduction was specific for RV-positive AGE and seen among children who were targeted for immunization as well as older groups, suggesting a herd-immunity effect.
CONCLUSIONS In this posthoc subgroup analysis, the vaccine reduced healthcare resource utilization attributable to rotavirus gastroenteritis,without increased risk of intussusception or other serious adverseevents, among infants in a resource-limited country.
Influenza
CONCLUSION: TIV administered to young infants beginning at 6 to 12 weeks of age is safe and immunogenic.
CONCLUSION: Influenza vaccine that was administered in the second or third trimester of gestation was safe in this study population.
Conclusions: Maternal influenza vaccination was significantly associated with reduced risk of influenza virus infection and hospitalization for an ILI up to 6 months of age and increased influenza antibody titers in infants through 2 to 3 months of age.
Effectiveness of inactivated influenza vaccine in children aged 9 months to 3 years: an observational cohort study. Santtu Heinonen MD a, Heli Silvennoinen MD a, Pasi Lehtinen MD a, Raija Vainionpää PhD b, Thedi Ziegler PhD c, Dr Terho Heikkinen MD
Interpretation – Trivalent inactivated influenza vaccine was effective in preventing influenza in young children, including those younger than 2 years. Our findings suggest that influenza vaccine recommendations should be reassessed in most countries.
Conclusion: In conclusion, these findings suggest that the H1N1 vaccine has a reasonable safety profile, and there is no evidence that the vaccine is associated with an increased risk of the Guillain–Barré syndrome.
Polio
Immunogenicity of bivalent types 1 and 3 oral poliovirus vaccine: a randomised, double-blind, controlled trial. Dr Roland W Sutter MD a , Prof T Jacob John FRCP[E] b, Prof Hemant Jain MD c, Prof Sharad Agarkhedkar MD d, Prof Padmasini Venkat Ramanan MD e, Harish Verma MB f, Jagadish Deshpande PhD g, Ajit Pal Singh MB h, Meghana Sreevatsava MPH a, Pradeep Malankar MD a, Anthony Burton a, Arani Chatterjee MB h, Hamid Jafari MD f, R Bruce Aylward MD a
Interpretation: The findings show the superiority of bOPV compared with tOPV, and the non-inferiority of bOPV compared with mOPV1 and mOPV3.
[...] The Vaccines [...]
yes. later i went down to India and stayed in the hoitspal. that time when my dad was so sick, they took him to take venogram to test for the drug activity. my dad was sick, on empty stomach was taken inside the x-ray room in the morning and was let go only by 3.00 pm. i will never forget the suffering that he underwent that day. he already had some skin problems due to immune deficiency. when they started dye injection in to his leg the skin peeled off and blood started coming. the docs never bothered and asked my brother to come inside and help since my dad was moving with pain. he went inside to hold him and when he came back he was on the verge of crying. later when my dad came back, he affected leg was in a mess, the docs didn’t bother to say a word, the attendant told us to ask ward nurse to do nursing. when we asked the ward nurse, she said she cannot do anyhting wothout doctor’s advise and dermatologist has to come. the dermatologist came only two days later and my dad had to suffer with open wound till then. this happened one month back, now my dad is back home, still the wound has not heeled in his leg.i wanted to write this incident becasue, even educated people are taken for a ride in our country. i was telling my brother in future never accept for any study, because, when it comes to that the doctors (for that matter anyone involved) will be concerned with the research only and patient’s condition is secondary. i have seen that personally in the study projects that i was involvedsorry for not writing in Tamil, as when i try to write, it comes as all sorts of codes. hope i will soon break the jinx and start wriitng in tamilraj
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